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<!DOCTYPE html> <html class="no-js"> <head profile=""> <!--[if IE]><![endif]--> <title>Coq10 and statins 2018</title> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <style type="text/css"> sup { vertical-align: super; font-size: smaller; }</style> </head> <body class="html not-front not-logged-in no-sidebars page-node page-node- page-node-24711 node-type-blog-post has-sticky-footer"> <!-- RTP Marketo Web personalization START --> <!-- RTP tag --> <!-- End of RTP tag --> <!-- RTP Marketo Web personalization END --> <!-- Google Tag Manager --> <div id="bounds"> <header> </header> <div class="region region-utility-bar"> <div id="block-block-11" class="block block-block"> <div class="content"> <ul class="header-upper-nav"> <li><span class="sprite-global sprite-global-CommunityIcon"></span><span class="head-link">Community</span></li> <li><span class="sprite-global sprite-global-BlogIcon"></span><span class="head-link">Blog</span></li> <li><span class="sprite-global sprite-global-ContactIcon_0"></span><span class="head-link contactUsTrack">Contact Us</span></li> <li><span class="head-link platformLoginTrack">Login</span></li> </ul> </div> </div> </div> <div class="logo-menu"> <div id="main-logo"><span class=""><img itemprop="logo" src="" alt="Veracode Logo"></span></div> <div class="region region-main-menu"> <div id="block-search-form" class="block block-search"> <div class="content"> <form action="/blog/research/cryptographically-secure-pseudo-random-number-generator-csprng" method="post" id="search-block-form" accept-charset="UTF-8"> <div> <div class="input-container flex flex--justify-content--center flex--align-items--center"> <!-- <img src="/sites/default/files/" class="close-btn icon-search" style="display:none;" > <img src="/sites/default/files/" class="search-btn icon-search searchTrack"> --> <div class="sprite-global sprite-global-SearchIcon_0 search-btn icon-search searchTrack"></div> <div class="sprite-global sprite-global-SearchIcon-Close close-btn icon-search"></div> </div> <div class="search-field"> <input title="Enter the terms you wish to search for." placeholder="Your search" id="edit-search-block-form--2" name="search_block_form" value="" size="15" maxlength="128" class="form-text st-default-search-input" type="text"> <input name="form_build_id" value="form-1BRjAfGf14XjJiL598BvNX8MOvU64hukmWei2lvujQg" type="hidden"> <input name="form_id" value="search_block_form" type="hidden"> </div> </div> </form> </div> </div> <br> <div class="region region-content"> <div id="block-system-main" class="block block-system"> <div class="content"> <div class="blog-home-page blog-main-wrap"> <div class="layout-standard-container blog_single_post" id="node-24711"> <div class="banner-wrapper"> <div class="container" style="overflow: inherit;"> <div class="col-md-10 col-md-offset-1"> <h1>Coq10 and statins 2018</h1> <!--/content--> </div> </div> </div> <div class="container"> <div class="col-md-10 col-md-offset-1"> <div class="contant-blog content-wrapper blog-inner-wrapper"> <div class="posted after-detail"> <div class="clearfix"> <div class="col-md-6 auther-name blogAuthorTrack"> <span class="author-img blogAuthorTrack"> <span class="blogAuthorTrack"> <img typeof="foaf:Image" src="alt=" msheth's="" picture="" title="msheth's picture"> <span class="overlay blogAuthorTrack"></span></span></span><span class="by"></span></div> </div> </div> <p> Individuals with diabetes, heart failure, and cancer have lower CoQ10 levels, and proactive supplementation can benefit those who have a risk of certain health issues. Page 1. To date, this is the only trial comparing intramuscular CoQ10 levels among the statins. Recently, polymorphisms in the coenzyme Q2 gene, important in the synthesis of CoQ10, was reportedly strongly associated with statin‐induced myopathy. In this article, we discuss the benefits, side effects, and recommended dosages of CoQ10. D. “This means that average or "normal" levels of CoQ10 are really suboptimal and the very low levels observed in advanced disease states represent only the tip of a deficiency ice berg. This is a patented process used by only the most reputable, higher quality From birth, the body starts to produce CoQ10. [1] CoQ10 can be taken at the same time as statin medication. (Medicine) Internal Medicine, Metabolic Medicine, Diabetes, Thyroid, Obesity, Antiaging, and Geriatric Consultant Sep 16, 2018 · Statins bring down the secretion of beneficial substances, such as CoQ10, which are released naturally when cholesterol is synthesized. Read honest and unbiased product reviews from our users. A 2019 randomized controlled trial investigated the effect of CoQ10 on statin-related muscle Setting aside the controversy about the rice supplement for a moment, the biggest takeaway is that any source of monacolin K, as well as most statins, can dramatically lower your body’s natural CoQ10 production. In a recent trial using simvastatin 80 mg/day, atorvastatin 40 mg/day, or placebo for 8 weeks , mean muscle concentrations of CoQ10 in the simvastatin-treated patients decreased by 34%. Oct 16, 2017 · CoQ10: Miracle Supplement or Waste of Money? Coenzyme Q10 is a naturally occurring antioxidant that our bodies need for energy. Think of CoQ10 as the spark plug of the body. (I usually recommend 200mg with food). Our aim was to investigate if 8 weeks of CoQ10 supplementation can improve glucose homeostasis in simvastatin-treated subjects. 7 Statins [3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA) inhibitors] are recommended as the treatment of first choice for management of hypercholesterolaemia and combined hyperlipidaemia by European guidelines for cardiovascular disease (CVD) prevention and lipid management. 1 However, statin‐induced myopathy, a main adverse effect of statins, is one of the primary reasons for statin discontinuation that contributes to adverse cardiovascular outcomes. Muscle aches are a common side effect of statins, and CoQ10 is important for muscle function, so scientists have wondered if raising blood levels of CoQ10 might relieve the aches. However, when you’re taking statins, CoQ10 levels are significantly lowered. Vegetarian CoQ10 sources coming from animals – dairy and eggs – actually provide very little. CoQ10 (also known as CoEnzymeQ10) is also critical in a very large number of cellular reactions that can soak up, absorb and detoxify damaging molecules called free radicals including Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS). Although in short term studies patients taking statin drugs show a lower incidence of heart disease and stroke, many patients feel years older while taking these drugs since the side effects mimic the aging Nov 20, 2019 · Therefore, CoQ10 plays a crucial role in the production of energy for cells which allows growth and optimal function. Jun 03, 2019 · What we do know is that CoQ10 supplementation may be useful for those taking statins, since it can lower side effects that they often cause. Coenzyme Q10 (CoQ10) is a nutrient that occurs naturally in the body. P. Qunol 100mg Ultra CoQ10 capsules make it possible for you to get optimal levels of Coenzyme Q10 at three times sooner, so you can experience the potential benefits faster. Кофермент Q (МНН: Ubidecarenone, Убидекаренон; также известен как кофермент Q10, . MYTH 3 Taking CoQ10 prevents muscle aches caused by statins. But this enzyme gives your muscle cells more energy — which may be why muscle pain is a common statin side effect. medicinescomplete. It contains 100% pure, top quality CoQ10 sourced from Ubiquinol, the active and most effective version of CoQ10, in the right dose, doesn’t have any binders or fillers, and is 100% safe to use. Certain medications may also lower your CoQ10 levels. the induction of coenzyme Q10 (CoQ10) after statin treatment and statin-induced myopathy. Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of Coenzyme Q10 and statin-related myopathy. CoQ10 supplements may help relieve muscle pain related to statin use. , and the American College of Cardiology says that statin therapy, which lowers cholesterol levels, reduces the risk of heart attack and stroke in Top 10 CoQ10 Product Reviews - JAN 2020. In respect to migraines, CoQ10 acts as an anti-inflammatory and boosts mitochondrial function, both of which help manage pain. 2, 2018). CoQ10 and Adrenal Health Apr 17, 2019 · One of the primary reasons people use coenzyme Q10 supplements is to mitigate the side effects of statins. Together, CoQ10 and vitamin E fight disease-causing free radicals. Learn more about how taking a supplement can affect statin side effects and your overall heart health. Do I need it? 19 July 2018 statin, myalgia, muscle pain, ubiquinone, myopathy CoQ10 depletion is a logical candidate as a cause of statin myopathy for the following 2018 Oct 2;7(19):e009835. each serving contains 200 mg of CoQ10 PureNature CoQ10 Plus contains 200mg of Ubiquinone; with no synthetic ingredients, cheap filler, binders and artificial colors. Sep 14, 2017 · Do you suffer fatigue, muscle pain, nerve pain? You may need CoQ10. Unfortunately, this is the same enzyme that produces not only CoQ10 but also ketones, which are crucial nutrients to feed your mitochondria. In mice, statins lower ATP levels, and impair energy metabolism. In contrast, other studies11–15 have suggested that there is no beneficial effect of CoQ10 supplementation. Apr 25, 2019 · Statins work by depleting a crucial liver enzyme used to make CoQ10 and cholesterol. CoQ10 supplementation is available as capsules, tablets, and by IV. While there are many reasons why we don’t recommend statins , if you are taking one then you must ensure you’re also taking CoQ10. Although CoQ10 may have benefits and is well tolerated, additional studies confirming the Q-SYMBIO findings are needed. By accident I stopped taking statins for a week and the palpations vanished completely . 1,2. * What is Jigsaw CoQ10 w/SRT®? CoQ10 w/SRT® uses the clinically shown MicroActive® CoQ10. So How Does CoQ10 Deal With Statins? CoEnzymeQ10 was developed by Merck in 1956 and since they could not patent it, they sold the rights to the Japanese 1974. In addition, if taken at higher doses, claims for heart and circulatory health benefits can be made, and can provide assurance of doubling CoQ10 levels in three weeks. This can lead to muscle weakness and general feelings of fatigue. e. If you are on statins, have gingivitis and reduced heart ejection fraction, take this supplement. The top 50 foods with CoQ10 Rather than list the absolute highest 50, which would primarily consist of the livers, hearts, and brains of various animals, we have compiled the top 10 for both meat and vegetables, and the top 5 for each other category. Statins are drugs used to decrease cholesterol. 009835. As we get older, the production of this critical antioxidant declines and we do not get its protective benefits. The question of whether CoQ10 can help treat statin myopathy is a common one encountered by clinicians in current day practice. Beef Liver CoQ10 Beef liver provides a slightly higher amount of CoQ10 than beef steaks, at 3. Researchers from the University of Queensland in Australia found that women face a 33% higher chance of developing Type 2 diabetes after age 75 if they had been prescribed statins for five or more years. CoQ10 also functions as an antioxidant and protects cells from free radicals and oxidative damage. If you’re taking statins to lower your cholesterol, you probably know that they also lower your natural levels of CoQ10. Judy summarizes the CoQ10 $30 billion per year in 2018 to nearly $70 million by 2030 [Bhatt & Butler 2018]. The effect of statins on muscle CoQ10 may be drug and dose dependent. A CoQ10 supplement is best taken in ubiquinol form. Which CoQ10 form is best? Jan 14, 2017 · 6 Advantages and Disadvantages of COQ10. Sep 09, 2015 · Coenzyme Q10 (CoQ10) ranks among the bestselling supplements, with global sales predicted to reach $849 million by 2020, according to a recent study. In fact, one study showed that CoQ10 supplementation prevents both plasma and platelet CoQ10 decrease, without affecting the cholesterol lowering effect of the drug. 17 of 22 products exceeded 100 mg of CoQ10 per serving, the threshold dose for possibly helping with hypertension and migraines. The researchers found both hydrophilic and lipophilic statins lowered blood CoQ10 levels in a similar manner. Does coenzyme Q10 help to reduce muscular issues and other negative side Was its depletion the cause of statin-induced muscle aches? A version of this article appears in print on Oct. CoQ10 and Statins go hand in hand, while almost everyone can benefit from supplementing CoQ10 levels with a quality Ubiquinol CoQ10 supplement it is vital for those taking a Statin drug to supplement their CoQ10 levels. 1161/JAHA. Low CoQ10 levels in patients on statins can contribute to the common side effects of statin therapy such as fatigue and aching joints and muscles. Apr 13, 2018 · Statins increase calcification in your arteries and rob your heart of CoQ10, a nutrient that keeps it strong. Medications alone aren't the only means to lower cholesterol levels. Coenzyme Q10 and statins: biochemical and clinical implications. When oxidized CoQ10 (ubiquinone) is used by the body, it transforms and becomes ubiquinol. Although statins are very effective, they are not suggested for everybody. The Supplement Industry’s DIRTY Secret. For more details, plus how to minimize the occurrence of CoQ10 side effects, see the Concerns and Cautions section of the CoQ10 and Ubiquinol Supplements Review. A 2019 randomized controlled trial investigated the effect of CoQ10 on statin-related muscle Jan 13, 2018 · It's great that your doctor is open to CoQ10. Effects of Statins on CoQ10 | SpectraCell Laboratories is the leader in innovative clinical testing including MicroNutrient Testing, Lipoprotein Particle Profile, Telomere Testing, Aspirin Response Testing and chemistry tests. Patients taking CoQ10 had significant reductions in blood sugar, markers of oxidative stress, and insulin resistance compared to the control group. ** In addition, CoQ10: Optimizes cellular energy production. Most heart patients are uneducated about the dangers of CoQ10 deficiency CoQ10 complex in crystalline form supports uniform absorption and time release claims. 9 mg for every 100 Statins interfere with the production of mevalonic acid, which is a precursor in the production of CoQ10. CoQ10 has a long history of use in protocols for those with heart failure. In 2018, researchers analyzed patients many years after supplementation with coenzyme Q10 and selenium. This has been shown to significantly decrease CoQ10 levels in the blood and muscle tissues ( 10 ). Jul 27, 2019 · CoQ10 will not cause serious side effects or issues for most people, but if you do have a heart condition, you should not be taking dietary supplements, except for under the supervision of your doctor. The heart, pancreas, kidneys, and liver often house CoQ10, which is ingested from seafood and meats. Co-enzyme Q10 (CoQ10) is an antioxidant produced by the cholesterol biosynthesis pathway. Athletes benefit Statins: Qu, J Am. This enzyme is also involved in the production of CoQ10, so statins reduce blood levels of it as well. Your cardiologist has likely suggested supplementing with CoQ10, also called coenzyme Q10, to avoid muscle pain and disease (heart problems, brain disorders, diabetes, and cancer have also been linked to low levels of CoQ10). CoQ10 is present and needed in every cell of the body and performs some very important tasks(1): CoQ10 helps cells convert food and nutrients into ATP, the energy molecule that is needed by every cell. When young, levels are high because the body knows it is a valuable antioxidant that serves growth and energy production. A deficiency can cause your heart to become stiff, this increases blood pressure, which can cause other cardiovascular diseases. It's not known if statins' effect on CoQ10 contributes to their adverse effects. As always, take good care. CoQ10 can also be found in certain foods, like grass-fed beef, pistachios, and broccoli. . 1 Apr 2013 There is no solid evidence that taking coenzyme Q10 prevents muscle problems related to taking a cholesterol-lowering statin drug. It is sold in the United States as a dietary supplement. According to CoQ10 expert Peter H. Should patients on statins take Coenzyme Q10 supplementation to reduce the risk of . Recently started having wild palpations [ thumping – flipping – missing beats ] but no chest pain which vanished when running but return shortly afterwards . People can get CoQ10 through foods and supplements. If you already have symptoms of Statin damage (such as muscle pain or memory loss), take 100 mg of CoQ10 3 times a day until symptoms subside. Here are some of the most useful Consumer Reviews Submitted: “I was advised by my doctor to take this CoQ10 for my heart, and to work against the side effects of statins. You should also avoid taking the best CoQ10 supplements, if you are on anticoagulant medicaments, like Warfarin, as this can affect the drug. Statins work by inhibiting an enzyme that's integral to cholesterol production in the body. Apr 12, 2018 · Or, if you’ve made poor lifestyle choices in the past, CoQ10 is a great way to jumpstart a healthy new lifestyle. From my point of view, if a doctor doesn’t insist that their statin patients take supplemental CoQ10—it’s sheer foolishness. CoQ10 Benefits Jan 05, 2018 · Abstract OBJECTIVE: Our objective was to assess effects of dietary supplementation with coenzyme Q10 (CoQ) on blood pressure and glycaemic control in subjects with type 2 diabetes, and to consider oxidative stress as a potential mechanism for any effects. While statins are designed to stop the body’s production of cholesterol, they also prevent CoQ10 production, as well. A 2018 27 Nov 2019 Cardiovasc Res 2018; 114:1073. Abstract. Dec 16, 2018 · Statins deplete Coenzyme Q10, which can have devastating effects. 25 Sep 2018 Coenzyme Q10 supplementation ameliorated statin‐associated Library with no language restrictions from inception to January 2018 to 5 Oct 2018 Q. side effects of statins is myalgia, which causes the patient to either stop their statin or significantly reduce the dose of their statin. Statins have been associated with an increased incidence of cataracts, cancer, peripheral neuropathies and some psychiatric disturbances. Although it isn’t the standard procedure, a great many naturopathic doctors advise that statin therapy be supplemented with CoQ10 to reduce the risk of congenital heart failure and decrease muscle pain associated with the use of traditional cholesterol-lowering medication. The speaker recommends 150 mg three times per CoQ10 finds its way into the top 11 because of its benefits across the health spectrum. 118. Introduction. B. Product Features. com. If you’re taking a statin medication to improve cholesterol, CoQ10 is a particularly vital supplement. One of the most common side effects of statin medication is muscle pain, and this may be a result of lowered levels of CoQ10. Our goal is to dispense important information to the inquisitive consumer about these products while maintaining an overall factual approach and assessment of what the products are all about. My husband is on statins and has been treated for blood pressure issues since the age of 20. In a 2018 study, CoQ10 was shown to significantly reduce the frequency, severity, and duration of migraine headaches —although it may take several months of taking it as a supplement for the effects to kick in. Dec 10, 2016 · The heart is one of the most metabolically active organs in our body and thus a deficiency in CoQ10 usually affects the heart first. CoQ10 acts as an antioxidant, which protects cells from damage and plays an important part Dec 28, 2018 · Let’s have a look at the biochemistry background behind this question: When our cells generate energy, glucose (from carbohydrates) or ketones (from fats) are converted into acetyl-CoA, which is then sent through the tricarboxylic acid (TCA) cycle Statins were hailed as miracle drugs when they were introduced in 1987. Statins lower CoQ10 levels in the heart, skeletal and liver tissues. It also contains Bioperine, a patented form of Piperine (Black Pepper Extract) which has been proven to increase the absorption of CoQ10 in the body. PureNature CoQ10 came in first based on quality, test, affordability, guarantee and customer service. Similarly, elderly people might also suffer due to lack of strength to take their statin drugs which can be overcome with the inclusion of dietary CoQ10 supplements. I tell my statin patients to take at least 200 mg of CoQ10 supplements daily, 100 mg in the morning, 100 mg at night. Those who are taking statins to lower cholesterol are at particular risk for deficiency, because not only do statins reduce cholesterol levels, but they also block Coenzyme Q10 synthesis in the body. Studies have shown that statin-induced deficiency of CoQ10 may be related to muscle pain. Migraines :. But that same pathway that blocks cholesterol also blocks the production of CoQ10 (co-enzyme Q10), a vitamin-like substance that is essential to the process of making energy within the mitochondria. Importantly, CoQ10 can be taken in addition to most cardiovascular medications. But which ones are really effective and will get you the results you are looking for? To help you choose, we did the research on hundreds of CoQ10 products. Oct 09, 2017 · Dr. , Practical Neurology, 2018. 4 You would need to eat just over 7 pounds of beef to get the equivalent of a 100 mg supplement of CoQ10. 7% excess of CoQ10 than what is reported on the label. This is possible since Qunol’s CoQ10 gelatin capsules supply 100 mg of CoQ10 with vitamin E, at 5. CoQ10 is used for energy production in the cells. Common signs that Dec 10, 2017 · Statins do a good job at blocking that LDL production. If you take Statins without taking Coenzyme Q10, you are risking your health. 2018. CoQ10 AntiAging Prevent Disease With This Discovery CoQ10 Is One of the Greatest Discoveries For Slowing the CoQ10 Benefits – More Energy – Better Health CoQ10: What is it? CoQ10 benefits the cells in our Heart Disease – What You Should Know When Taking Statins Half of all Heart Failure Occurs Because the Heart Can’t CoQ10 has been an adjunct to standard therapies for CVD, particularly CHF, in multiple studies. Nature Made is the #1 Pharmacist Recommended brand of Coenzyme Q10 (CoQ10), * and 4 Nature Made CoQ10 products are USP verified for quality and purity. 2018 11:55 am GMT+0000 anyone taking statins may have reduced levels of CoQ10-ubiquinol. Arch Neurol 2005 20 Oct 2019 The most common and effective ones are statins, inhibitors of the 3-hydroxy-3- methyl-glutaryl-coenzyme A . This interview originally aired July 1, 2017. May 28, 2019 · CoQ10 plays a role in producing ATP in the body, so in a sense, it's like a cup of coffee for your cells! Maintaining sufficient levels of CoQ10 boosts cellular energy production and keeps your body systems and organs function as they should. It also helps restore CoQ10 that may be depleted by age or the use of statins. Taking a statin to lower "bad" LDL cholesterol also lowers CoQ10, a naturally occurring chemical in the body involved in energy production in cells. 1 supplement recommended by cardiologists to all patients; Anyone taking a statin drug to lower their cholesterol must take a CoQ10/ubiquinol supplement to protect their health, especially their heart health, as statins deplete your body of CoQ10 Statins Can Lower Your CoQ10 Levels. Chaturvedi M. Dec 05, 2019 · Although statins reduce cholesterol production, they also lower CoQ10 levels. In May 2000, the FDA warned about liver failure with regard to statin drugs. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. This means that CoQ10 functions both as an energy producer and as an antioxidant. The risk of Written by Jillian Kubala, MS, RD on September 4, 2018 Other causes of CoQ10 depletion include statin medication use, heart disease, nutrient deficiencies, Coenzyme Q10 might help reduce the muscle aches some people experience while taking cholesterol-lowering drugs known as statins. Jan 28, 2018 · Statins lower your cholesterol, which is an important precursor for many of your steroid hormones, including progesterone, testosterone, aldosterone, cortisol and vitamin D; Statin drugs deplete your body of CoQ10, vitamin K2, dolichol and selenium, and prevent the production of HMG co-enzyme A reductase (an enzyme your liver uses to make ketones) In a 2018 study, 50 people with diabetic neuropathy were given either 100 milligrams (mg) of CoQ10 a day or a placebo for 12 weeks. Fix one problem and create another. Because CoQ10 has important functions in the body and because people with some diseases have CoQ10 can enhance blood flow and protect blood vessels via the preservation of nitric oxide. To learn more about the available Ubiquinol products and brands, visit our Buyer’s Guide. Dec 17, 2019 · This supplement from Doctor’s Best uses science-based nutrition to provide you with a formula that encourages heart health and energy production in the cardiovascular system. 1, 2 The efficacy of these agents in decreasing low-density Nov 09, 2018 · Statin Users, CoQ10 Is Your New Best Friend; Statin Users, CoQ10 Is Your New Best Friend. Therefore, it is absolutely vital to supplement with CoQ10 if you're taking a statin drug. Although statins reduce cholesterol production, they also lower CoQ10 levels. 53 ounces) portion of beef sirloin provides 3. CoQ10 can come in a variety of foods in our diet – though they might not all sound appealing. Because coenzyme Q10 plays a role in muscle cell energy production, some researchers have proposed that taking a coenzyme Q10 supplement might reduce the risk of muscle-related side effects. It's also important to supplement right from the start. This is because statins inhibit the natural production of CoQ10 by the body. Some over-the-counter alternative high cholesterol treatments can help -- but others don In a placebo-controlled study of heart failure patients, the group supplementing with CoQ10 had improved exercise capacity, decreased occurrence of cardiac-related events—and a significantly reduced, overall cardiac-related mortality. ** Converts into Ubiquinol, a powerful anti-aging antioxidant. Heart disease was the leading cause of death in the U. This enzyme is also involved in the production of CoQ10, so statins reduce blood levels of it as well (certain other drugs, such as some beta-blockers and antidepressants, also reduce CoQ10). Reduced CoQ10 levels can lead to mitochondrial dysfunction, which can cause muscle pain, or myopathy. Statins lower cholesterol by inhibiting the enzyme in your liver that produces cholesterol (HMG coenzyme A reductase). Given that some patients may have a tendency to overestimate the risk of adverse effects, being able to provide reassurance that nine out of 10 patients do not experience muscle pain with statins can lay a useful foundation for a discussion about coenzyme Q10. Statins side effects, benefits, risks and danger, natural alternatives, muscle damage, use of CoQ10 August 28 2018 by Ray Sahelian, M. The mitochondria cells in the heart need Coq10 to function properly and keep the heart healthy. Statin medications work by inhibiting cholesterol synthesis, which impedes the shared pathway that produces CoQ10. Loading. CoQ10 is also in many foods we eat. For changes in intramuscular CoQ10, Choi et al documented that statins decreased CoQ10 levels in cardiac muscle and skeletal muscle. CoQ10 promotes heart and cardiovascular health, maintaining healthy blood pressure levels already in a normal range. Jun 11, 2018 · A decrease in body levels of CoQ10 may, in theory, increase the likelihood of muscle symptoms in people taking statins. CoQ10 and Ubiquinol are commonly recommended heart health supplements used by those taking statin medications to help increase levels of CoQ10 and Ubiquinol in the body. The Importance of CoQ10 CoQ10 is a proenzyme that is naturally produced by the body and found in nearly every cell. CoQ10 is an antioxidant our body basically makes from scratch using the same enzyme we use to make cholesterol—that is, the same enzyme that’s blocked by cholesterol-lowering statin drugs. doi: 10. It has been suggested that external CoQ10 nutritional dosage may reduce the risk of cell damage and decrease the risk of heart diseases, as well as cancer. Ubiquinol is often labelled as “CoQ10 Ubiquinol” and is typically stocked in the same area as conventional CoQ10 supplements. FACLM on November 13th, 2018 Given that, should statin users take CoQ10 supplements? No, they should 24 Apr 2019 Coenzyme Q10 is a dietary supplement, and use of it as a treatment for cancer in humans has been investigated in only a limited manner. Coq10 for heart health and heart energy. ** Thrasher, Jacob (2018) Targeting Metastatic Breast Cancer with Statin Drugs and CoQ10. In fact, the Journal of the American Heart Association in October of 2018 published results from a meta-analysis of 12 trials on this topic. In combination of taking it with multi B vitamin, magnesium, and butterbur, I have gone from having 20 migraines to 3 or less a month- depends on the weather. The bioavailability of a given CoQ10 supplement depends on the lipid carrier it is immersed in and any preservatives added. And unfortunately, most people are tricked into thinking all CoQ10 is the same. Cancer. “Why is CoQ10 Good for you?” And so people taking statins might also want to consider taking CoQ10. Supplementation of CoQ10 with vitamin E has been shown to markedly decrease atherosclerosis and inflammation, both of which are precursors to heart disease, in baboons and mice. Learn what this co-enzyme does and what can affect its levels in your body. In order to counter the muscle pain produced by Lipitor, the solution may seem simple: Take CoQ10 supplements. Mammen AL. 2018 Story Highlights. We calculated the inception to January 2018 to identify all existing literature. You can find CoQ10 supplements virtually everywhere. So, if CoQ10 production gets caught in the crossfire, then maybe that explains why statins increase our risk of diabetes—namely, by accidently also Dec 23, 2019 · Dr Deepak Anjana V. Sep 23, 2014 · Jarrow Formulas Ubiquinol QH-Absorb, 100 mg, 120 Count. Cholesterol Control: The Alternatives. High blood pressure, arrhythmia, angina, and even heart failure have all been associated with CoQ10 deficiency. 2 Coenzyme Q10 (CoQ10) supplementation is the most popular therapy for statin myalgia among both physicians and patients despite limited and conflicting evidence of its efficacy. Wow. Aug 19, 2015 · Studies have shown that CoQ10 can significantly reduce the appearance of wrinkles. Medical subject 2 Aug 2019 Coenzyme Q10 (CoQ10), found in all human cells, is involved in cellular respiration and energy production. The moment one takes a statin, the availability of CoQ10 for anti-oxidation is compromised allowing excess oxidative damage to our mitochondrial DNA. 2 Researchers have attributed the reduced CoQ10 levels to the ability of statins to inhibit a key step in the synthesis of CoQ10, so some experts have recommended that statin users take CoQ10 supplements to CoQ10 is essential to this process due to its electron transfer characteristics and is in fact a vital factor for 95% of the overall energy production at the cellular level. Jan 17, 2019 · CoQ10 and Statins. Top 10 Best CoQ10 Supplements Reviews in 2018 Aging can cause us to lose coenzyme Q10 which can upset blood pressure and cause cellular weakness. A previous meta-analysis, performed by Banach et al,16 failed to validate the benefit of CoQ10 supplementation on statin-induced myopathy, which did not include the latest Nov 09, 2018 · Coq10 Dosage When considering the use of herbal supplements, seek the advice of your doctor. Piperine, which is sometimes added to CoQ10 supplements to increase bioavailability, may also cause side effects, and may interact with certain medications. ; Oct 12, 2016 · My husband and I have taken Qunol Mega CoQ10 for several years now. A 100 grams (3. CoQ10 supplementation ameliorated statin-induced myopa-thy. As a coenzyme, its function is to assist the performance of body processes such as digestion. Last accessed March 25, 2018. People taking statins can experience side effects such as muscle pain, nausea and diarrhea, liver and kidney damage, and even increased blood sugar or type 2 diabetes. A side effect of long-term statin use is a CoQ10 deficiency. It’s also sometimes used to combat the negative effects of statins, drugs which lower blood lipid levels and help prevent heart attacks . Dec 03, 2019 · CoQ10 is a natural chemical that carries out a many vital roles in the body. Statins can lower your body’s level of CoQ10. Made in the USA with all-natural, fast dissolving veggie capsule and are made in an FDA registered laboratory that is cGMP Sep 04, 2018 · Statins also interfere with the production of mevalonic acid, which is used to form CoQ10. CoQ10 MD provides an efficient dosage of 250 mg of Ubiquinol CoQ10 a day. Statins not only decrease the cholesterol in the body, but the levels of CoQ10 in the liver as well. This may lead to an increase of unpleasant symptoms. Of the 26% of American adults aged 40+ taking statins in 2012, as many as 10. Vitamin C is a "natural" HMG-CoA reductase inhibitor. 06 mg of CoQ10. It is also a powerful supporter of cognitive function and brain health. CoQ10 is an antioxidant that our cells need to make energy (it's part of the ATP production pathway in the mitochondria - if you remember your high school biology). Just as a car can’t function without an A side effect of statin drugs is muscle problems. Does that sound familiar? CoQ10 Benefits Lowering low‐density lipoprotein (LDL, aka bad cholesterol) with statins reduces heart disease risks by up to 40% in a wide range of patients, but many will also have serious muscle pains (myopathy) and stop treatment altogether. What About Mustard for Cramps? One reason CoQ10 is being studied for potential use as a blood pressure and heart failure therapy is that the current medications, generally a class of drugs called statins – which are very effective for reducing cholesterol levels and preventing heart attack and stroke – increase the risk of diabetes and accelerates muscle loss. taking statins, A 2018 randomized trial compared the effects of 200 mg daily doses of ubiquinone and ubiquinol Trans-form CoQ10 is identical to the CoQ10 produced naturally within the body, and if you read the studies on CoQ10 like I have, you'll notice that most research is conducted using trans-form CoQ10. 9, 2018 , Section D, Page 4 of 1 Nov 2009 Question: I've been put on simvastatin and a friend told me I should be taking coenzyme Q10 to help prevent muscle pain. Coenzyme Q10 (CoQ10) is an essential component of the mitochnodria that produce power for the body’s cells, and plays a critical role in the manufacture of ATP, the energy that drives all body processes. Statins are conventionally used to prevent and treat coronary heart disease with a good safety and well‐tolerated profile. My husband is a 66-year-old diabetic taking metformin and atorvastatin. BMJ Learning - Take the Test. ” The Vitamin C Connection. CoQ10 not only is important when it comes to thyroid health, but it also plays an important role in adrenal health, and some studies show that it can help with other conditions. 4-6. Supplements offer CoQ10 in either the oxidized form (ubiquinone) or the reduced form (ubiquinol). 19 Sep 2017 Previous studies have already reported that suppression of CoQ10 by statins increased oxidative stress affecting mitochondria in skeletal 7 Jul 2016 Of the 26% of American adults aged 40+ taking statins in 2012, as many as 10. This may be hard to swallow (excuse the pun) but it should be illegal to prescribe a statin without also prescribing CoQ10. It revealed CoQ10 supplements eased statin-related muscle pain better than a placebo. Following your doctor prescribed cholesterol-lowering regimen that may include eating healthy, exercising regularly, and taking cholesterol medication such as statins can help keep your cholesterol in check. CoQ10 also acts as a powerful antioxidant, protecting your cells and tissues from harmful free radicals. A 2019 randomized controlled trial investigated the effect of CoQ10 on statin-related muscle A 2018 meta-analysis concluded that there was preliminary evidence for oral CoQ 10 reducing statin-associated muscle symptoms, including muscle pain, muscle weakness, muscle cramps and muscle tiredness. Apr 24, 2017 · Statins Reduce Ketone Production. However, regular CoQ10 is fat-soluble, so it is best absorbed with foods that contain fats. But what exactly is CoQ10, and do we really need a supplement for it? Find helpful customer reviews and review ratings for Pure CoQ10 (High Potency 200mg) - High Absorption CoQ-10 Enzyme Ubiquinone Supplement Pills, Extra Antioxidant Coenzyme Q10 Vitamin Tablets, CoQ 10 for Healthy Blood Pressure & Heart at Amazon. In general, statins are very well tolerated and about 85-90% of patients report no side effects. Dec 09, 2018 · CoQ10 is a nutrient whose production tends to become down-regulated by two main sources: genetic mutations involved in its synthesis (a primary deficiency) and statins, which inhibit an enzyme (hydroxymethylglutaryl coenzyme A) involved in the development of CoQ10 (considered a secondary deficiency) (Potgieter, Pretorius, & Pepper, 2013). Nov 20, 2017 · It’s also the No. Statin users routinely have low CoQ10 levels when it is tested. Best of all, even at very high doses, CoQ10 has virtually no side effects. Thanks to CoQ10, this energy breathes life into your body and keeps it functioning optimally. References “Coenzyme Q10 – Topic Overview” Published NA. Stephen Sinatra's own research to find the best type of CoQ10. Sep 13, 2019 · The new study also compared the effects of different types of statins on CoQ10, and these results are surprising. of 2018 published results from a meta-analysis of 12 trials on this topic. Jan 14, 2017 Sep 14, 2016 by Editor in Chief. Nov 14, 2017 · The first supplement widely publicized to reduce muscle soreness caused by taking statins was coenzyme Q10 (CoQ10). This is why many cardiologists advise their patients to supplement with CoQ10. 2018 Effects of coenzyme Q10 on statin-induced myopathy: a In his book, Insider's Guide to Coenzyme Q10, Dr. Reviewed in May 2018 by: . Nov 21, 2019 · Statins have been found to reduce the amount of naturally occurring coenzyme Q10 in the body. Jul 09, 2015 · If you are on statins or you exercise regularly: 400 mg of CoQ10 daily or 100 mg of ubiquinol daily; Since CoQ10 is fat-soluble, it’s better absorbed by the body if taken with a meal that contains fat. CoQ10 is an antioxidant that works to protect cells from the negative effects of aging. The Different Redox Forms of Coenzyme Q10. Kushan Karunaratne et al. Taking statins (such as those prescribed to lower cholesterol levels) can put people at greater risk of deficiency. We are in our 60's and worry about health risks as we age. Aug 06, 2018 · Jarrow Formulas QH-Absorb, 100mg, 60 SoftgelsAt a Glance:The active antioxidant form of CoQ10Supports heart function and antioxidant status*Utilizes the Q-absorb natural, proliposomal delivery system for enhanced absorptionDesigned for those who seek the superior absorption of ubiquinol (QH) for cardiovascular and antioxidant health*Particularly useful to older consumers who may not activate Jul 28, 2019 · A study of 126 heart failure patients over the course of six years not only underscored the important of optimal levels of CoQ10, but shed light on the impact of statins on reducing CoQ10 to dangerous levels. Dec 17, 2018 · CoQ10 is needed to regenerate vitamin E after it has neutralized a free radical. There are multiple forms of CoQ10 available, but are you taking the right form for your needs? Take our quiz to find out and talk to your doctor about Ubiquinol. heart, liver). ‡ CoQ10 is naturally orange and found in most cells in the body. The UMM also suggests that taking it at night may increase your body’s ability to absorb it. , Langsjoen P. One indication may be if you’re currently taking statins, or struggling with adverse effects caused by previous Research has shown that production of CoQ10 is interrupted by statins making your natural CoQ10 levels drop by as much as 40%. com on 10/12/2018. Accessed via http://www. The depletion of CoQ10 by statins has been theorized to be an underlying cause of one of the primary side effects of statin use, muscle Conclusions: CoQ10 does not appear to decrease the rate of myalgia when et al, 2018, Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Can dietary supplements keep myalgia in check so that patients adhere to statins ? A 2015 meta-analysis of randomized controlled trials found that CoQ10 had no effect on statin myopathy. After reading this you should have a better understanding as to why some people with thyroid and autoimmune thyroid conditions can benefit from supplementing with CoQ10. Heart 2018, 13, 143–163. The hypothesis is that, if you decrease the CoQ10 levels, you reduce the production of energy in muscle cells and they won't function as well, leading to muscle aches, weakness or inflammation. Often statin users can suffer from myopathy or muscular weakness. Introduction One of the main side effects of statins is myalgia or muscle pain. A 2018 meta-analysis 1 Apr 2015 Statins (Hydroxy-methylglutaryl CoA reductase inhibitors) are routinely prescribed to treat hypercholesterolemia because they inhibit 3 Aug 2019 This 2015 review summarizes multiple mechanisms by which statins pathways, inhibit the synthesis of coenzyme Q10 (CoQ10) and heme A, 14 Nov 2017 Statin side effects cause many patients to stop statin therapy. It is important to note that pharmaceutical treatment with statins (cholesterol lowering medications) can inhibit CoQ10 activity and lead to a serious deficiency. Apr 07, 2017 · (Low CoQ10 levels in patients on statins can contribute to the common side effects of fatigue and aching joints and muscles. Treatment with statins has been associated with reduced plasma CoQ10 levels, and it has been hypothesised that supplementation with CoQ10 may assist with management of statin-associated muscle symptoms (SAMS). As we age, our body’s production of CoQ10 often decreases, driving the need to supplement our natural production with the substance from other sources. CoQ10 helps support cellular energy production in the mitochondria – the powerhouses of most cells. CoQ10 also has anti-inflammatory properties that can impact your heart health, blood sugar regulation, and energy levels for the better. Ubiquinol is the active form of CoQ10. ) CoQ10 supplements have long been made in Japan by a yeast fermentation process. 7 Jul 2016 Of the 26% of American adults aged 40+ taking statins in 2012, as many as 10. Your Guide To The Top 3 CoQ10 Supplements Of 2019 Updated 01/03/2020 The Amazing Health Benefits of CoQ10 + How to Choose the Right Supplement . Discover whether ubiquinol CoQ10 is better than ubiquinone, and get the surprising results from Dr. , M. All purchases from PureNature is backed by a 365 day Risk Free 100% Money Back Guarantee. The highest sources of CoQ10 are found in animal organ meats (i. CoQ10 dosage has been promoted as an effective nutritional supplement, that may prevent many other health problems like diabetes, high cholesterol and periodontal gum disease. You may have heard of coenzyme Q10 (CoQ10) as a potential option to counteract these muscle Nov 13, 2018 · Despite how widely they are prescribed, statins are associated with many side effects and can deplete levels of CoQ10 in the body. Statins block a precursor of CoQ10, which is a critical ingredient in the production of adenosine triphosphate (ATP), an energy-carrying molecule, generated by cells. Given the consequences of stopping needed medications in heart failure, advise patients to continue their chronic heart medications. This a major reason why taking statins drugs is no guarantee you will not die of a heart attack. Dec 05, 2019 · CoQ10 carries out several vital roles, including promoting energy production and neutralizing harmful particles called free radicals. Было подчеркнуто, что, помимо снижения концентраций CoQ10 в плазме, лечение статинами также приводит к снижению . Statins inhibit the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, . It is a critical component of cellular respiration and production of ATP, the primary fuel used in cell function. Jul 10, 2019 · Lipitor and other statins seem to lower the CoQ10 your body naturally produces, according to the Mayo Clinic. It's also sold as a dietary supplement and touted as a way to boost energy and "support heart function," as the product labels assert. This is also why it is so important that CoQ10 be taken at the same time, and preferably slightly ahead of, a statin. Coenzymes are small organic molecules that bind to enzymes and are essential Started statins about 3 years ago for marginally high cholestorol . CoQ10 also acts as an antioxidant that protects our tissues from free radicals and oxidative damage. Statins are used to reduce an enzyme in the liver that not only decreases the production of cholesterol, but also further lowers the natural production of CoQ10. As of 2014 no large well-designed clinical trials of CoQ 10 in cancer treatment had been conducted. Langsjoen, MD. Feb 09, 2014 · CoQ10 deficiency also accelerates DNA damage, and because CoQ10 is beneficial to heart health and muscle function this depletion leads to fatigue, muscle weakness, soreness and eventually heart failure. Not only is it a powerful antioxidant to fight against the oxidative stress that occurs in diabetes. Mar 05, 2018 · Some studies have shown that statins decrease the concentration of CoQ10 in both muscle tissue and in the bloodstream. There are also higher levels of CoQ10 in the regular (muscle) meat in animals, some oils (i. CoQ10, also Myalgia is considered to affect around 10 per cent of people taking statins. If any CoQ10 supplement is going to work for you, this is it. Researchers report that CoQ10 may have significant benefits for people with cardiovascular disease (CVD), from reducing risk for repeat heart attacks and improving outcomes in patients with heart failure to lowering blood pressure and helping CoQ10 supplements are fast becoming the most popular path to whole-body health. November 2018 Issue . Some statins are better absorbed when taken without food, so, if yours is one of them, it would be better to take CoQ10 separately with a meal that contains fats or oils (preferably unsaturated Statins work by inhibiting an enzyme in the liver that’s integral to cholesterol production. Coenzyme Q10 (CoQ10) is a vitamin-like substance made naturally by the body that is involved in energy production in all your cells. A 2015 meta-analysis of randomized controlled trials found that CoQ10 had no effect on statin myopathy. More recently, a compound called Solanesol, a precursor of CoQ10, has been extracted from tobacco leaves and converted to CoQ10. A deficiency in CoQ10 can adversely affect a person’s health. May 18, 2018 · To avoid contributing to bodily dysfunction it is important to understand the significance of CoQ10, how statins affect it, and how to maintain appropriate CoQ10 levels. CoQ10 can help counter some negative side effects caused by statins. olive or soybean oil), and nuts. The most common side effect of statins is muscle pain. Likewise, both low-middle intensity and high intensity statin therapy has similar effects. S. Dietary sources of CoQ10 include meat, fish, and whole grains, but the amount of CoQ10 in these sources isn’t enough to significantly increase CoQ10 levels in our body. Heart conditions. Multiple studies have shown a decrease in CoQ10 levels after taking statins, which scientists have noted in both serum and muscle tissues. But whether or not CoQ10 supplements are effective is a lot less clear. If you want to try a CoQ10 supplement, then Research Verified should be your first choice. Jun 12, 2018 · ROACH: I am writing to inquire about the effects of statins on the body. Heart Association 2018. 5 % have reported symptoms of muscular myopathy, such as investigating the effect of CoQ10 on statin-induced myopathy. The clinical implications of this decrease are not known, but the decrease may be associated with some of the observed side effects. What is CoQ10? Coenzyme Q10 is a nutrient belonging to a class of compounds called ubiquinones. Statin myalgia was confirmed in 120 patients with prior symptoms of statin myalgia using an 8-week randomized, double-blind Jan 17, 2019 · Coenzyme Q10 (CoQ10) is a substance that is naturally present in the human body, with the highest levels in the heart, liver, kidneys, and pancreas. Ask your health practitioner or local pharmacist for the best product for you with thes questions. Nobody had ever heard of CoQ10 until 1956 when scientists at the University of Wisconsin isolated a crystalline compound from beef heart mitochondria. People who deplete their Coq10 supplies by taking statin drugs need to supplement with Coq10 to replenish and strengthen the heart muscle. Through mevalonate blockade, statins directly inhibit CoQ10 synthesis making mitochondrial damage and mutation all but inevitable. We know that statins deplete CoQ10, but doctors have yet to come to a consensus on the long-term implications of this. Statin-Associated Muscle coenzyme Q10 level in statin-related myopathy. Updated June 12, 2018. These coenzymes can boost immunity, support heart health, increase energy levels, and much more. Statins have many harmful side effects. the complicated relationship between Coenzyme Q10 and statin medications. Lipitor and other statins have been shown to lower the levels of naturally occurring CoQ10 within the body, which is often already deficient in middle-aged individuals. It is also used as a dietary 19 Nov 2018 2018 Cholesterol Clinical Practice Guidelines: Executive Summary. • Also, check to see if the CoQ10 is made using natural fermentation. Stephen Kopecky, a Mayo Clinic cardiologist, debunks myths about statins. Undergraduate thesis, under the direction of Yu-Dong Zhou and Dale Nagle from Chemistry and Biochemistry and BioMolecular Sciences, University of Mississippi. 9 Jan 2018 It has been also observed that low levels of vitamin D and coenzyme Q10 ( CoQ10) might increase the risk of statin intolerance; however, The magnitude of the reduction of CoQ10 in combination with statins has C- reactive protein in women with type 2 diabetes, Mahsa Gholami et al, 2018 [51]. What Are Statins? Statins are a class of prescription drugs designed to lower high cholesterol. Statins clearly help to lower the risk for future ASCVD events in patients at risk. There are many CoQ10 products out there, some obviously better than others. May 05, 2019 · Coenzyme Q10 (CoQ10) supplementation has been found to improve glucose homeostasis in various patient populations and may increase muscle glucose transporter type 4 content. 5% have reported symptoms of muscular myopathy, such as muscle pain, cramps, spasms, or weakness as a result of treatment [1,2]. 5 % have reported symptoms of muscular myopathy, such as 13 Nov 2018 Written By Michael Greger M. Furthermore, the inhibitory effect of statins on dolichol synthesis makes repair of DNA damage all the more difficult because of the vital role of dolichols in glycoprotein (glycohydrolase) synthesis. Statins can also cause a harmful muscle-wasting disease called rhabdomyolysis. CoQ10 supplements have been flooding the market ever since research began showing how critical these coenzymes are to our health. Given how broadly your body uses coenzyme Q10, it shouldn’t be a surprise that it’s involved in a wide range of disease progressions. However, there are a few side effects that tend to raise concern among patients when considering the need for one these medications. Littarru G. “CoQ10″ Natural Eye Care” Published NA. 7 products had more than 150 mg of CoQ10 per serving, the dose typically administered for CoQ10 deficiency, a known Apr 11, 2018 · Consumer Advisors provides detailed reviews about the various health products on the market today. Dosage of CoQ10 is 100–200 mg/d with food. CoQ10 (ubiquinone) for Dietary Supplementation: "So far, this CoQ10 has really worked in preventing my horrible migraines. Or you can take a quality CoQ10 supplement. I have to admit I am at a total loss why any doctor would prescribe a statin medication without adding the life-saving CoQ10. The depletion of CoQ10 by statins has been theorized to be an underlying cause of one of the primary side effects of statin use, muscle pain and breakdown, or statin-induced myopathy, which affects approximately 10% to 25% of CoQ10 protects the mitochondria, the powerhouse of the cells, and these are usually the first affected by health concerns. Is CoQ10 An Antidote to Cramps from Statins? A recent meta-analysis of 12 randomized controlled trials found that coenzyme Q10 (CoQ10) supplements eased SAMS better than placebo (Journal of the American Heart Association, Oct. They include muscle pain (myalgia), fatigue, exercise intolerance (muscles too painful and weak to exercise), memory loss, peripheral neuropathy (tingling, numbness or burning pain in the hands, arms, feet or legs), irritability, sleep problems, and sexual dysfunction (such as erectile dysfunction). coq10 and statins 2018</p> <div class="auther-bottom-section"> <div class="row"> <div class="col-sm-9 col-md-9 col-lg-10 by-author"> <div class="social-bootom"> </div> </div> <!--/icon-social--> </div> </div> <!--/author-info--> <div class="blog-bottom-blocks-wrapper"> <div id="block-block-56" class="block block-block"> <div class="content"> <div class="social-icons-strip"><span><br> </span></div> </div> </div> <div id="block-disqus-disqus-comments" class="block block-disqus"> <div class="content"> <div id="disqus_thread" class="blog-disqus-comments_area"> <noscript></noscript> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </body> </html>
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